Table 1 Association of CD27 and CD117 antigen expression patterns with baseline clinical and biological characteristics in MM patients
From: Prognostic value of the expression of CD27 and CD117 in newly diagnosed multiple myeloma patients
Characteristic | CD27- (n = 89) | CD27+ (n = 71) | P value | CD117- (n = 90) | CD117+ (n = 70) | P value |
|---|---|---|---|---|---|---|
Sex, n(%) | 0.845 | 0.780 | ||||
Male | 45(50.60) | 37(52.10) | 47(52.20) | 35(50.00) | ||
Female | 44(49.40) | 34(47.90) | 43(47.80) | 35(50.00) | ||
Age(yrs), mean ± s.d. | 59.13 ± 10.56 | 60.07 ± 8.57 | 0.546 | 58.62 ± 9.84 | 60.74 ± 9.46 | 0.171 |
Immunoglobulin isotype, n(%) | 0.367 | 0.712 | ||||
Immunoglobulin G (IgG) | 37(41.57) | 33(46.48) | 41(45.56) | 29(41.43) | ||
Light chain type | 29(32.58) | 16(22.54) | 23(25.56) | 22(31.43) | ||
Othersa | 23(25.85) | 22(30.98) | 26(28.88) | 19(27.14) | ||
ISS stage, n(%) | 0.005** | 0.086 | ||||
I + II | 38(42.70) | 46(64.79) | 43(47.78) | 43(61.43) | ||
III | 51(57.30) | 25(35.21) | 47(52.22) | 27(38.57) | ||
DS stage, n(%) | 0.182 | 0.071 | ||||
I + II | 16(17.98) | 19(26.76) | 15(16.67) | 20(28.57) | ||
III | 73(82.02) | 52(73.24) | 75(83.33) | 50(71.43) | ||
First-line treatment, n(%) | 0.001** | 0.001** | ||||
Proteasome inhibitor (PI)-based programmesb | 63(70.79) | 64(90.14) | 61(67.78) | 66(94.28) | ||
Immunomodulator (IMiD)-based programmesc | 3(3.37) | 4(5.63) | 5(5.56) | 2(2.86) | ||
Monoclonal Antibody Combination Programmesd | 23(25.84) | 3(4.23) | 24(26.66) | 2(2.86) | ||
Autologous stem cell transplantation (ASCT), n(%) | 32(35.96) | 22(30.99) | 0.509 | 33(36.67) | 21(30.00) | 0.376 |
BMPC(%), M(P25, P75) | 34.5(19.00, 54.50) | 21(10.00, 34.00) | <0.0001*** | 27.00(13.88, 48.38) | 28.00(12.88, 46.88) | 0.551 |
β2-MG(mg/L), M(P25, P75) | 5.27(3.31, 9.98) | 3.48(2.69, 6.29) | 0.006** | 4.34(3.04, 10.35) | 3.63(2.95, 6.43) | 0.092 |
Hb(g/L), mean ± s.d. | 90.21 ± 26.47 | 101.38 ± 27.06 | 0.010* | 92.72 ± 29.28 | 98.32 ± 24.17 | 0.198 |
PLT(×109/L), M(P25, P75) | 179.00(127.00, 238.50) | 186.00(124.00, 247.00) | 0.712 | 179.00(120.50, 243.75) | 183.50(138.50, 242.25) | 0.807 |
Calcium(mmol/L), M(P25, P75) | 2.27(2.14, 2.37) | 2.23(2.16, 2.36) | 0.735 | 2.27(2.16, 2.36) | 2.24(2.12, 2.39) | 0.711 |
LDH (U/L), M(P25, P75) | 168.00(146.50, 194.50) | 172.00(136.00, 210.00) | 0.826 | 176.00(151.75, 214.00) | 161.50(135.00, 190.25) | 0.029* |
ALP (U/L), M(P25, P75) | 65.00(51.00, 91.00) | 74.00(57.00, 91.00) | 0.404 | 74.00(55.00, 106.25) | 63.00(51.00, 81.50) | 0.016* |
CK(U/L), M(P25, P75) | 48.00(31.50, 77.00) | 53.00(38.00, 70.00) | 0.531 | 45.50(32.75, 68.00) | 57.25(37.75, 88.25) | 0.081 |
CREA(umol/L), M(P25, P75) | 70.10(60.00, 115.00) | 68.00(53.10, 125.30) | 0.290 | 74.60(58.80, 129.43) | 66.30(55.62, 91.00) | 0.073 |
ALB(g/L), M(P25, P75) | 37.10(32.95, 41.90) | 37.60(32.70, 42.30) | 0.884 | 37.60(32.70, 42.10) | 37.35(33.00, 41.68) | 0.914 |
TP(g/L), M(P25, P75) | 72.20(63.60, 102.40) | 73.60(62.30, 100.80) | 0.491 | 71.80(63.08, 106.35) | 74.00(63.27, 100.93) | 0.990 |
GLB(g/L), M(P25, P75) | 33.80(22.35, 70.80) | 31.90(21.10, 63.20) | 0.292 | 30.85(21.60, 78.13) | 33.80(21.95, 68.25) | 0.736 |
A/G, M(P25, P75) | 1.10(0.40, 1.90) | 1.20(0.50, 1.80) | 0.598 | 1.30(0.40, 1.83) | 1.05(0.50, 1.90) | 0.893 |
URIC(umol/L), M(P25, P75) | 395.00(307.00, 511.70) | 373.00(308.00, 424.00) | 0.200 | 395.00(317.00, 484.25) | 369.50(306.50, 426.00) | 0.288 |
UREA(mmol/L), M(P25, P75) | 5.60(4.60, 8.52) | 5.89(4.80, 8.49) | 0.638 | 5.98(4.38, 9.66) | 5.57(4.68, 7.46) | 0.400 |