Table 2 Demographic, clinical, and Immunologic characteristics of patients with AGS
All | Children ≤ 18 years | Adults | Comparison (p value children vs. adults) | |
|---|---|---|---|---|
Number (percentage) | 57 (100) | 38 (66.7) | 19(33.3) | |
Age in years median (range) | 12 (2.25–61) | 8 (2.25–18) | 28 (20–61) | |
Male sex (%) | 26(45.6) | 19 (50) | 7(36.8) | 0.41 † |
Symptoms | ||||
Hives alone (%) | 16(28.1) | 11(28.9) | 5 (26.3) | >0.99 † |
Anaphylaxis (%) | 39 (68.4) | 26 (68.4) | 13 (68.4) | >0.99 † |
+ GIT (%) | 21(36.8) | 13 (34.2) | 8 (42.1) | >0.58† |
GIT alone (%) | 1 (1.8) | 1 (2.6) | 0 (0) | |
Abdominal pain (%) | 13 (22.8) | 8 (21.1) | 5 (26.3) | >0.74 † |
Respiratory (%) | 29 (50.8) | 19 (50) | 10 (52.6) | >0.99 † |
Grade 5 anaphylaxis (%) | 17 (29.8) | 11 (28.9) | 6 (31.6) | >0.99 † |
Timing | ||||
0-<1 hour (%) | 14 (24.5) | 10 (26.3) | 4 (22.2) | >0.76 † |
>1-≤2 hours (%) | 10 (18.2) | 6 (16.2) | 4 (22.2) | 0.71† |
≤ 2 hours (%) | 24 (43.6) | 16 (43.2) | 8 (44.4) | >0.99 † |
>2 hours (%) | 31 (56.4) | 21 (56.8) | 10 (55.6) | >0.99 † |
Uncertain (%) | 2 (3.5) | 1(2.6) | 1 (5.3) | |
Atopy/Out of 50 (%) | 18/50 (36) | 11/33 (33.3) | 7/17 (41.2) | >0.76 † |
Tick bite/Out of (%) | 23/47 (48.9) | 18/32 (56.2) | 5/15 (33.3) | 0.21 † |
IgE to Alpha-gal > 0.35 IU/mL (%) | 57 (100) | 38 (100) | 19 (100) | |
IgE to alpha-gal IU/mL GM (range) | 18.36 (0.95–87.1) | 22.3 (0.95–87.1) | 12.99(1.24–38.8) | 0.064 †† |
IgE to beef/pork/mutton* > 0.35 IU/mL/Out of (%) | 54/54 (100) | 35/35(100) | 19/19 (100) | |
IgE to beef/pork/mutton IU/mL GM (range) | 7.16 (0.36–53.1) | 8.73(0.36–53.1) | 4.98(0.37–22.7) | 0.12 †† |
IgE to BSA > 0.35 IU/mL **/Out of (%) | 1/52 (1.9) | 1/33 (3.0) | 0/19 (0) | |
IgE to alpha-gal>IgE to beef/pork #/Out of (%) | 53/54 (98.1) | 35/35 (100) | 18/19 (94.7) | |