Table 1 Clinical baseline characteristics of healthy controls and patients with sepsis
Parameters | Controls (n = 92) | Sepsis patients (n = 116) | P value |
|---|---|---|---|
Demographics | |||
 Age (years), mean ± SD | 55.77 ± 9.02 | 53.76 ± 8.48 | 0.101 |
 BMI (kg/m2), mean ± SD | 23.73 ± 4.25 | 24.26 ± 4.17 | 0.365 |
 Male, n (%) | 45 (48.91) | 68 (58.62) | 0.207 |
 Smoke, n (%) | 40 (43.48) | 54 (46.55) | 0.676 |
 Drink, n (%) | 41 (44.57) | 57 (49.14) | 0.576 |
Medical history, n (%) | |||
 Hypertension | 31 (33.70) | 46 (39.67) | 0.390 |
 Hyperlipidemia | 37 (40.22) | 39 (33.61) | 0.385 |
 Diabetes | 32 (34.78) | 47 (40.52) | 0.472 |
Biochemical indicators, median (IQR) | |||
 Scr (mg/dL) | 0.85 (0.72, 1.01) | 1.60 (1.16, 2.05) | < 0.001 |
 Albumin (g/L) | 44.76 (39.42, 51.63) | 32.42 (25.64, 38.31) | < 0.001 |
 WBC (× 109/L) | 5.92 (5.07, 6.85) | 18.37 (15.25, 22.67) | < 0.001 |
 CRP (mg/L) | 4.95 (3.96, 6.93) | 106.47 (79.91, 136.31) | < 0.001 |
Disease severity, mean ± SD | |||
 SOFA score |  | 7.00 (4.00, 9.00) | - |
 APACHE II score |  | 18.50 (14.00, 23.00) | - |
Inflammatory cytokine, median (IQR) | |||
 TNF-α (pg/mL) | 29.70 (23.76, 36.63) | 199.00 (150.98, 250.47) | < 0.001 |
 IL- 6 (pg/mL) | 13.12 (9.90, 18.12) | 51.48 (37.62, 72.27) | < 0.001 |
 IL- 8 (pg/mL) | 15.35 (12.87, 20.79) | 112.34 (81.51, 142.51) | < 0.001 |
 IL- 1β (pg/mL) | 25.25 (19.31, 32.18) | 182.16 (137.12, 216.32) | < 0.001 |