Table 2 Estimates of PK parameters of VRC07-523LS from a base two-compartment popPK model
Parameter | Description | Estimate | 95% CI | % RSE |
|---|---|---|---|---|
Fixed Effects | ||||
 F | Bioavailability | 0.47 | (0.45, 0.49) | 2.50 |
 Ka (/day) | Absorption rate constant | 0.34 | (0.27, 0.43) | 11.75 |
 CL (L/day) | Clearance rate | 0.12 | (0.11, 0.13) | 2.61 |
 Vc (L) | Central volume | 3.88 | (3.56, 4.23) | 4.36 |
 Q (L/day) | Inter-compartmental clearance | 0.30 | (0.26, 0.35) | 7.83 |
 Vp (L) | Peripheral volume | 3.60 | (3.34, 3.89) | 3.85 |
Random Effects | ||||
 ωCL | SD, clearance | 0.29 | (0.25, 0.33) | 6.52 |
 ωVc | SD, central volume | 0.40 | (0.34, 0.46) | 7.44 |
 ωQ | SD, inter-compartmental clearance | 0.57 | (0.45, 0.73) | 12.65 |
 ωVp | SD, peripheral volume | 0.24 | (0.19, 0.29) | 10.57 |
Error Model Parameters | ||||
 σ1 | SE, additive error | 0.13 | (0.09, 0.19) | 20.39 |
 σ2 | SE, proportional error | 0.14 | (0.13, 0.15) | 3.45 |