Fig. 5

Distributions of covariate-adjusted individual-level PK features via the targeted maximum likelihood estimation (TMLE) method (Approach 1). Each dot indicates the TMLE-adjusted PK feature estimate for each participant as if all 146 received VRC07-523LS alone (left box), or all 146 received VRC07-523LS in combination with other mAbs (right box) via TMLE. The mid-line of the box denotes the median and the ends of the box denote the 25th and 75th percentiles. The whiskers at the top and bottom of the box extend to the most extreme data points that are no more than 1.5 times the interquartile range (i.e., height of the box) or if no value meets this criterion, to the data extremes. Abbreviations: TMLE- Targeted maximum likelihood estimation; CL- clearance rate; Vc- central volume; Q- inter-compartmental clearance; Vp- peripheral volume; AUC- area under the curve; IV- intravenous