Fig. 4

Effects of TAMI-M on Polyinosinic: polycytidylic acid-induced production of proinflammatory chemokines in HORS Cells. A mRNA expression levels of CXCL9, CXCL10, and CXCL11 in human ORS cells treated with Poly I: C (10 µg/mL) and TAMI-M (100 nM) for 24 h. B mRNA expression levels of CXCL9, CXCL10, and CXCL11 in human ORS cells treated with Poly I: C, TAMI-M, and the positive control Ruxolitinib (100 nM) for 24 h. Statistical significance was determined using one-way ANOVA followed by post hoc comparisons (Tukey’s test). Significant differences are denoted as *p < 0.05, **p < 0.01, and ***p < 0.001 between groups. This figure illustrates the differential impact of TAMI-M and Ruxolitinib on the expression of chemokines associated with AA pathogenesis