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Table 1 Pathway enrichment results for the total population

From: Single-cell characterization of the immune heterogeneity of pulmonary hypertension identifies novel targets for immunotherapy

 

group

Description

pvalue

ratio

GO:0033077

C1

T cell differentiation in thymus

##################

25

GO:0045059

C1

positive thymic T cell selection

##################

15

GO:0030217

C1

T cell differentiation

##################

30

GO:0002260

C1

lymphocyte homeostasis

##################

20

GO:0070661

C1

leukocyte proliferation

##################

30

GO:2,000,271

C2

positive regulation of fibroblast apoptotic process

0.005809945

9.090909091

GO:0006470

C2

protein dephosphorylation

0.006333995

18.18181818

GO:0045654

C2

positive regulation of megakaryocyte differentiation

0.006389249

9.090909091

GO:2,001,256

C2

regulation of store-operated calcium entry

0.009281166

9.090909091

GO:0031643

C2

positive regulation of myelination

0.00985863

9.090909091

GO:0019886

C3

antigen processing and presentation of exogenous peptide antigen via MHC class II

##################

33.33333333

GO:0002495

C3

antigen processing and presentation of peptide antigen via MHC class II

4.7068302614186E-13

33.33333333

GO:0002504

C3

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

##################

33.33333333

GO:0002478

C3

antigen processing and presentation of exogenous peptide antigen

##################

33.33333333

GO:0019884

C3

antigen processing and presentation of exogenous antigen

4.5704204447935E-12

33.33333333

GO:0071621

C4

granulocyte chemotaxis

##################

42.10526316

GO:0030595

C4

leukocyte chemotaxis

##################

47.36842105

GO:0097529

C4

myeloid leukocyte migration

##################

47.36842105

GO:0097530

C4

granulocyte migration

1.1389874848663E-12

42.10526316

GO:0030593

C4

neutrophil chemotaxis

##################

36.84210526

GO:0060706

C5

cell differentiation involved in embryonic placenta development

##################

15

GO:0001892

C5

embryonic placenta development

0.000105193

15

GO:0098869

C5

cellular oxidant detoxification

0.000149244

15

GO:0097284

C5

hepatocyte apoptotic process

0.000200088

10

GO:0033209

C5

tumor necrosis factor-mediated signaling pathway

0.000244527

15

GO:0007585

C6

respiratory gaseous exchange by respiratory system

##################

21.42857143

GO:0043129

C6

surfactant homeostasis

##################

14.28571429

GO:0048286

C6

lung alveolus development

0.000637117

14.28571429

GO:0140962

C6

multicellular organismal-level chemical homeostasis

0.001301037

14.28571429

GO:0007162

C6

negative regulation of cell adhesion

0.001393518

21.42857143

GO:0030199

C7

collagen fibril organization

##################

21.05263158

GO:0030198

C7

extracellular matrix organization

##################

26.31578947

GO:0043062

C7

extracellular structure organization

##################

26.31578947

GO:0045229

C7

external encapsulating structure organization

##################

26.31578947

GO:0085029

C7

extracellular matrix assembly

##################

15.78947368

GO:0006956

C8

complement activation

3.323539105868E-07

23.52941176

GO:0006958

C8

complement activation, classical pathway

##################

17.64705882

GO:0002455

C8

humoral immune response mediated by circulating immunoglobulin

##################

17.64705882

GO:2,000,146

C8

negative regulation of cell motility

##################

29.41176471

GO:0040013

C8

negative regulation of locomotion

##################

29.41176471

GO:0035633…41

C9

maintenance of blood–brain barrier

##################

17.64705882

GO:0007189

C9

adenylate cyclase-activating G protein-coupled receptor signaling pathway

1.0305787824359E-05

23.52941176

GO:0043114

C9

regulation of vascular permeability

##################

17.64705882

GO:2,000,351

C9

regulation of endothelial cell apoptotic process

##################

17.64705882

GO:0072577

C9

endothelial cell apoptotic process

##################

17.64705882

GO:0071280

C10

cellular response to copper ion

##################

20

GO:0072012

C10

glomerulus vasculature development

0.00010888

20

GO:0061437

C10

renal system vasculature development

0.000124078

20

GO:0061440

C10

kidney vasculature development

0.000124078

20

GO:0035633…50

C10

maintenance of blood–brain barrier

0.000175563

20