Detecting the preoperative peripheral blood systemic immune-inflammation index (SII) as a tool for early diagnosis and prognosis of gallbladder cancer

Table 6 Cox multivariate analysis of IRFs for the poor prognosis in GBC patients

Variable	P value	HR	HR 95% CI
Age	0.477	1.434	0.531–3.876
Sex	0.851	1.097	0.419–2.871
Tumor size	0.612	0.732	0.220–2.437
Differentiation degree	0.405	0.645	0.230–1.81
TNM staging	0.818	0.88	0.295–2.623
Lymph node metastasis	0.893	0.936	0.361–2.429
Perineural invasion	0.646	1.217	0.526–2.814
Surgery type	0.456	0.657	0.218–1.982
CEA	0.093	0.764	0.557–1.046
CA125	0.068	0.973	0.945–1.002
CA19-9	0.042	1.022	1.001–1.044
SII	0.022	1.003	1.001–1.006

Note: TNM: T:extent of the primary tumor; N: lymph node involvement; M: metastatic disease; CEA: carcinoembryonic antigen; CA125: carbohydrate antigen 125; CA19-9: carbohydrate antigen 19 − 9; SII: System immune inflammation index. P < 0.05 indicated a statistically significant difference

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