Table 1 Preoperative CEA, CA125, and CA19-9 combined with SII have high early diagnostic value for GBC patients

CEA

55.81%

80.74%

0.774

< 0.001

CA125

53.49%

88.89%

0.686

< 0.001

CA19-9

50.00%

81.11%

0.686

< 0.001

SII

63.89%

98.89%

0.794

< 0.001

Combination

72.09%

91.11%

0.872

< 0.001

CEA vs. Combination

P = 0.003

CA125 vs. Combination

P < 0.001

CA19-9 vs. Combination

P < 0.001

SII vs. Combination

P = 0.003