Exploring the associations of plasma proteins with frailty based on Mendelian randomization

BMC Immunology

Table 2 Associations of plasma protein concentrations and the increased risk of frailty (top 5)

	No. of SNPs	β	se	P-value	OR (95%CI)	P_{Cochran’s Q}	P_MR−Egger	P_FDR
APOB
IVW	16	0.051	0.008	5.62E-11	1.053 (1.037,1.069)	0.058		1.28E-07
MR-Egger	16	/	/	/	/		0.946
Weighted median	16	0.047	0.010	4.01E-06	1.049 (1.028,1.070)
Maximum-likelihood	16	0.052	0.010	2.23E-07	1.053 (1.033,1.074)
MR-PRESSO	16	0.051	0.010	1.22E-04	1.053 (1.032,1.073)
CYP3A4
IVW	11	0.093	0.014	1.46E-11	1.098 (1.068,1.128)	0.760		6.66E-08
MR-Egger	11	/	/	/	/		0.631
Weighted median	11	0.106	0.019	3.97E-08	1.112 (1.071,1.155)
Maximum-likelihood	11	0.094	0.014	3.48E-11	1.099 (1.069,1.130)
MR-PRESSO	11	0.093	0.011	8.60E-06	1.098 (1.074,1.122)
STOM
IVW	4	0.154	0.025	1.35E-09	1.167 (1.110,1.226)	0.150		1.54E-06
MR-Egger	4	/	/	/	/		0.796
Weighted median	4	0.124	0.035	4.07E-04	1.132 (1.057,1.212)
Maximum-likelihood	4	0.157	0.034	4.73E-06	1.170 (1.094,1.252)
MR-PRESSO	4	0.154	0.034	1.99E-02	1.167 (1.092,1.247)
KCNMB3
IVW	15	0.058	0.009	1.66E-10	1.060 (1.041,1.079)	0.107		2.52E-07
MR-Egger	15	/	/	/	/		0.424
Weighted median	15	0.046	0.012	2.13E-04	1.047 (1.022,1.072)
Maximum-likelihood	15	0.059	0.011	1.17E-07	1.060 (1.038,1.084)
MR-PRESSO	15	0.058	0.011	1.24E-04	1.060 (1.037,1.083)
LRRK2
IVW	6	0.114	0.019	1.76E-09	1.120 (1.080,1.163)	0.386		1.61E-06
MR-Egger	6	/	/	/	/		0.039
Weighted median	6	0.099	0.024	4.61E-05	1.104 (1.053,1.158)
Maximum-likelihood	6	0.115	0.020	5.85E-09	1.122 (1.079,1.166)
MR-PRESSO	6	0.114	0.019	2.03E-03	1.120 (1.079,1.164)

Abbreviations: CI, confidence interval; FDR, false discovery rate; IVW, inverse variance weighted; MR-PRESSO, MR pleiotropy residual sum and outlier; OR, odds ratios; SNP, single nucleotide polymorphisms

ISSN: 1471-2172