Table 1 Associations of plasma protein concentrations and the reduced risk of frailty (top 5)
From: Exploring the associations of plasma proteins with frailty based on Mendelian randomization
|  | No. of SNPs | β | se | P-value | OR (95%CI) | PCochran’s Q | PMR−Egger | PFDR |
|---|---|---|---|---|---|---|---|---|
BIRC2 | Â | Â | Â | Â | Â | Â | Â | Â |
IVW | 6 | -0.022 | 0.006 | 2.92E-04 | 0.978 (0.967,0.990) | 0.099 | Â | 2.91E-02 |
MR-Egger | 6 | / | / | / | / | Â | 0.008 | Â |
Weighted median | 6 | -0.025 | 0.006 | 7.04E-05 | 0.975 (0.963,0.987) | Â | Â | Â |
Maximum-likelihood | 6 | -0.022 | 0.008 | 7.74E-03 | 0.978 (0.963,0.994) | Â | Â | Â |
MR-PRESSO | 6 | -0.022 | 0.008 | 4.49E-02 | 0.978 (0.963,0.994) | Â | Â | Â |
PSME1 | Â | Â | Â | Â | Â | Â | Â | Â |
IVW | 3 | -0.066 | 0.015 | 1.92E-05 | 0.936 (0.909,0.965) | 0.268 | Â | 4.87E-03 |
MR-Egger | 3 | / | / | / | / | Â | 0.667 | Â |
Weighted median | 3 | -0.068 | 0.016 | 2.00E-05 | 0.934 (0.905,0.964) | Â | Â | Â |
Maximum-likelihood | 3 | -0.066 | 0.016 | 2.50E-05 | 0.936 (0.908,0.965) | Â | Â | Â |
TMEM106B | Â | Â | Â | Â | Â | Â | Â | Â |
IVW | 3 | -0.089 | 0.023 | 1.30E-04 | 0.915 (0.874,0.957) | 0.108 | Â | 1.70E-02 |
MR-Egger | 3 | / | / | / | / | Â | 0.063 | Â |
Weighted median | 3 | -0.106 | 0.026 | 4.60E-05 | 0.899 (0.854,0.946) | Â | Â | Â |
Maximum-likelihood | 3 | -0.090 | 0.024 | 1.66E-04 | 0.914 (0.872,0.958) | Â | Â | Â |
LYPLAL1 | Â | Â | Â | Â | Â | Â | Â | Â |
IVW | 2 | -0.095 | 0.026 | 3.03E-04 | 0.909 (0.864,0.957) | 0.835 | Â | 2.94E-02 |
Maximum-likelihood | 2 | -0.095 | 0.027 | 4.20E-04 | 0.909 (0.862,0.959) | Â | Â | Â |
CDH1 | Â | Â | Â | Â | Â | Â | Â | Â |
IVW | 3 | -0.074 | 0.018 | 3.82E-05 | 0.928 (0.896,0.962) | 0.236 | Â | 7.26E-03 |
MR-Egger | 3 | / | / | / | / | Â | 0.091 | Â |
Weighted median | 3 | -0.067 | 0.019 | 4.02E-04 | 0.935 (0.901,0.971) | Â | Â | Â |
Maximum-likelihood | 3 | -0.075 | 0.018 | 4.93E-05 | 0.928 (0.895,0.962) | Â | Â | Â |