Fig. 1

Differentially expressed genes (DEGs) in the NC/Nga murine model. Volcano plots of DEGs detected in the skin (A) and muscle (C). The red and blue dots represent the upregulated and downregulated genes, respectively. Left panel: Upregulated and downregulated genes in NC/Nga mice compared to controls. Right panel: Upregulated and downregulated genes in hydrocortisone (Hc)-treated NC/Nga mice compared to untreated NC/Nga mice. Correlation of log₂-transformed fold change (log₂FC) between NC/Nga and control mice (x-axis) and between Hc-treated NC/Nga and untreated NC/Nga mice (y-axis) in the skin (B) and muscle (D). Each dot represents a different gene. The log₂FC between NC/Nga and control mice was negatively correlated with the log₂FC between Hc-treated NC/Nga mice and untreated NC/Nga mice, suggesting that the dysregulated genes in NC/Nga mice were largely recovered after Hc treatment. DEG: Differentially expressed gene, Hc: Hydrocortisone, log₂FC: Logarithm base 2-transformed gene expression fold change