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Table 2 Validation results of different screening conditions

From: Warning values of serum total kappa/lambda ratio for M-proteinemia

 

MM

LPL

WM

SMM

MGRS

MGCS

MGUS

AL

 

n

43

4

2

1

13

5

20

18

 

Condition

Sensitivity

%

Specificity%

A

97.67

100

100

100

69.23

80

75

66.66

77.42

A or B

100

100

100

100

76.92

80

80

83.33

72.9(Note)

A or C

97.67

100

100

100

76.92

80

80

66.66

70.95

Satisfies any of A, B and C

100

100

100

100

84.62

80

85

83.33

66.51

  1. A, K/L < 1.43 or K/L > 2.31, B two or more indicators decrease among IgA, IgG and IgM, C, IgA or IgM alone elevate, MM Multiple myeloma, LPL Lymphoplasmacytic lymphoma, WM Waldenstrom macroglobulinemia, SMM Smoldering multiple myeloma, MGRS Monoclonal gammopathy of renal significance, MGCS Monoclonal gammopathy of clinical significance, MGUS Monoclonal gammopathy of undetermined significance, AL Amyloidosis
  2. Note: The 85.76% new false negative patients were concentrated in TCL and patients receiving immunosuppressive therapy