Fig. 1

The impact of autoimmunity in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS): (1): Distribution of immune phenotypes. (2) The effect autoantibodies have in cell-mediated dysregulation and dynamics. (3) Cytokine involvement in molecular processes and pathology. (4) Genetics of ME/CFS autoimmunity. Abbreviations: HLA, human leukocyte antigen; NF-kB, nuclear factor kappa B; PTPN22, protein tyrosine phosphatase non-receptor type 22; CTLA4, cytotoxic T-lymphocyte associated protein 4; TNFα, tumour necrosis factor alpha; IFNγ, interferon gamma; ME/CFS, myalgic encephalomyelitis/chronic fatigue syndrome; NK, natural killer. Illustrated by JB using Adobe Illustrator 2024