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Table 2 Adjusted associations of quartiles of serum immunoglobulins concentrations to T2DM (n = 7,093) a

From: Serum immunoglobulin concentrations and risk of type 2 diabetes mellitus in adults: a prospective cohort study from the TCLSIH study

 

Quartiles of immunoglobulins concentrations

P for trend b

Level 1

Level 2

Level 3

level 4

IgG concentration (mg/dL, range)

517.0–1,050.0

1,060.0–1,200.0

1,210.0–1,340.0

1,350.0–3,330.0

-

No. of subjects

1,868

1,762

1,607

1,856

-

Person-years of follow-up (n)

7,492

6,762

6,538

7,054

-

No. of T2DM

163

118

91

86

-

Model 1 c

1.00

0.80 (0.63, 1.01) d

0.64 (0.50, 0.83)

0.56 (0.43, 0.72)

< 0.0001

Model 2 e

1.00

0.88 (0.70, 1.12)

0.74 (0.57, 0.96)

0.66 (0.51, 0.86)

< 0.001

Model 3 f

1.00

0.88 (0.69, 1.12)

0.72 (0.55, 0.94)

0.63 (0.48, 0.84)

< 0.001

Model 4 g

1.00

0.89 (0.70, 1.13)

0.73 (0.56, 0.95)

0.62 (0.47, 0.83)

< 0.01

Model 5 h

1.00

0.89 (0.70, 1.13)

0.77 (0.59, 1.01)

0.64 (0.48, 0.85)

< 0.01

IgE concentration (IU/mL, range)

5.00-10.3

10.4–28.2

28.3–80.4

80.5-4,420.0

-

No. of subjects

1,777

1,772

1,770

1,774

-

Person-years of follow-up (n)

7,257

6,862

6,915

6,812

-

No. of T2DM

108

109

111

130

-

Model 1 c

1.00

1.06 (0.81, 1.38)

1.08 (0.83, 1.40)

1.27 (0.99, 1.64)

0.05

Model 2 e

1.00

1.00 (0.77, 1.31)

0.93 (0.71, 1.22)

1.05 (0.81, 1.36)

0.56

Model 3 f

1.00

0.99 (0.75, 1.29)

0.94 (0.72, 1.24)

1.06 (0.81, 1.37)

0.48

Model 4 g

1.00

1.00 (0.77, 1.31)

0.93 (0.71, 1.21)

1.04 (0.80,1.36)

0.59

Model 5 h

1.00

0.97 (0.74, 1.28)

0.88 (0.67, 1.16)

0.94 (0.72, 1.23)

0.84

IgM concentration (mg/dL, range)

7.18–67.8

67.9–93.8

93.9–129.0

130.0-583.0

-

No. of subjects

1,774

1,779

1,744

1,796

-

Person-years of follow-up (n)

6,908

6,948

6,805

7,185

-

No. of T2DM

161

132

102

63

-

Model 1 c

1.00

0.82 (0.65, 1.03)

0.64 (0.50, 0.82)

0.38 (0.28, 0.51)

< 0.0001

Model 2 e

1.00

0.92 (0.73, 1.16)

0.87 (0.67, 1.12)

0.64 (0.47, 0.87)

< 0.01

Model 3 f

1.00

0.92 (0.73, 1.16)

0.90 (0.70, 1.16)

0.70 (0.52, 0.95)

0.02

Model 4 g

1.00

0.90 (0.71, 1.13)

0.90 (0.69, 1.16)

0.70(0.52, 0.95)

0.03

Model 5 h

1.00

0.89 (0.71, 1.13)

0.88 (0.68, 1.14)

0.68 (0.50, 0.92)

0.02

IgA concentration (mg/dL, range)

6.67–166.0

167.0-222.0

223.0-289.0

290.0–1,230.0

-

No. of subjects

1,789

1,770

1,735

1,799

-

Person-years of follow-up (n)

7,019

7,114

6,910

6,802

-

No. of T2DM

102

88

112

156

-

Model 1c

1.00

0.84 (0.63, 1.12)

1.16 (0.88, 1.52)

1.49 (1.16, 1.93)

< 0.0001

Model 2 e

1.00

0.86 (0.64, 1.14)

1.14 (0.87, 1.49)

1.44 (1.13, 1.86)

< 0.001

Model 3 f

1.00

0.93 (0.70, 1.24)

1.29 (0.98, 1.70)

1.71 (1.31, 2.22)

< 0.0001

Model 4 g

1.00

0.93 (0.70, 1.24)

1.30 (0.99, 1.72)

1.70 (1.31, 2.22)

< 0.0001

Model 5 h

1.00

0.93 (0.70, 1.25)

1.33 (1.01, 1.75)

1.62 (1.24, 2.11)

< 0.001

  1. a T2DM, type 2 diabetes mellitus; IgG, immunoglobulin G; IgE, immunoglobulin E; IgM, immunoglobulin M; IgA, immunoglobulin A.
  2. b Analysis by Cox proportional hazards model.
  3. c Model 1 was crude model.
  4. d Hazard ratio (95% confidence interval) (all such values).
  5. e Model 2 was adjusted for age, sex and obesity.
  6. f Model 3 was adjusted for variables in model 2 plus waist circumference, smoking status, drinking status, hypertension, hyperlipidemia, nonalcoholic fatty liver disease, eosinophil proportion counts, inflammatory diseases, family history of cardiovascular disease, hypertension, hyperlipidemia and T2DM and immunoglobulin mutually adjusted.
  7. g Model 4 was adjusted for variables in model 3 plus high-sensitivity C-reactive protein, estimated glomerular filtration rate, fibrinogen, erythrocyte sedimentation rate and alanine aminotransferase.
  8. Model 5 was adjusted for variables in model 4 plus fast blood glucose.
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BMC Immunology

ISSN: 1471-2172

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