The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to severe COVID-19 in the Iranian population

Table 3 The frequency of the KIR genotypes and haplotypes in the study population

KIR	severe disease n = 198	mild disease n = 196	severe vs. mild
KIR	N %F	N %F	p-value OR (95% CI)
AA genotype	34 16.7%	25 12.8%	NS
Bx genotype	164 82.8%	171 87.2%	NS
Bx genotype	N = 164	N = 171
C4Tx genotype	38 23.17%	54 31.57%	NS
CxT4 genotype	10 6%	10 5.8%	NS
C4T4 genotype	6 3.6%	7 4.09%	NS
CxTx genotype	110 68.12%	100 58.4%	NS
A haplotype	208 52.5%	173 44.1%	0.02* 1.4 1.058–1.855
B haplotype	188 47.4	219 55.8%	0.02* 0.714 0.539–0.945
C4 gene cluster	45 27%	63 36.4%	NS
T4 gene cluster	16 9.6%	18 13.8%	NS

The frequencies of the haplotypes A and B were determined by the following formulas [26]: Haplotype A: 2nAA + nAB/2 N, Haplotype B: 2nBB + nAB/2 N. (nAA: number of AA genotype, nAB: number of AB genotype, nBB: number of BB genotype). *p < 0.05: statistically significant; based on two-tailed Chi square with Yates’ correction [25]. NS = non-significant

ISSN: 1471-2172