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Table 2 The effect of BCG vaccination on unstimulated cytokine responses

From: The influence of neonatal BCG vaccination on in vitro cytokine responses to Plasmodium falciparum

 

RPMI

Uninfected erythrocytes

Cytokine

GMRa (95% CI)

p-valueb

GMRa (95% CI)

p-valueb

 

IFN-γ

1.6 (0.7–3.3)

0.24

1.3 (0.7–2.3)

0.41

TNF-α

1.0 (0.8–1.3)

0.96

0.94 (0.7–1.2)

0.65

IL-6

0.7 (0.3–1.4)

0.32

0.6 (0.3-1.0)

0.05

IL-1β

0.6 (0.3–1.6)

0.34

0.4 (0.2–0.9)

0.04

IL-10

1.1 (0.51–2.5)

0.76

1.2 (0.6–2.5)

0.59

MIG

0.84 (0.7–1.1)

0.13

0.8 (0.7–1.1)

0.12

IL-8

0.8 (0.3–2.1)

0.68

0.8 (0.5–1.3)

0.34

IP-10

1.2 (0.7-2.0)

0.57

0.7 (0.4–1.2)

0.16

MCP-1

1.0 (0.4–2.7)

0.98

0.9 (0.5–1.8)

0.76

MIP-1α

0.8 (0.4–1.6)

0.50

0.7 (0.4–1.1)

0.13

GM-CSF

1.0 (0.4–2.6)

0.94

1.3 (0.5–3.7)

0.57

  1. a Univariate analysis for the effect of BCG vaccination following stimulation with RPMI or uninfected erythrocytes. GMR > 1.0 indicates cytokine levels were higher in BCG-vaccinated neonates compared to BCG-naive neonates
  2. b p-value < 0.05 depicted in bold
  3. Abbreviations: 95% CI, 95% confidence interval; GMR, geometric mean ratio
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BMC Immunology

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