Fig. 4

Population frequency of Spike-specific immune responses. a Pie charts showing percentage of participants with SARS-CoV-2 spike (S)-specific IgG above (dark blue) and below (light blue) 3000 AU/mL at each visit. b Pie charts showing percentage of participants with SARS-CoV-2 S-specific CD4 + (top panel) and CD8 + (lower panel) T cells above (dark blue) or below (light blue) background response analysed by AIM after stimulation with the S-large pool