Table 2 Difference of lymphocyte subpopulation percentages between baseline and after completion of CT-RT and two and four weeks after completion HDR and PDR Brachytherapy

p

p

p

p

p

p

p

HDR

Total lymphocytes

< 0.1558

< 0.0566

< 0.7776

< 0.6015

< 0.0566

< 0.1200

< 0.6881

B-cells CD19⁺

< 0.0083

< 0.0020

< 0.0002

< 0.1729

< 0.1729

< 0.0346

< 0.0020

Total T-cells CD3⁺

< 0.0342

< 0.0105

< 0.7548

< 0.0158

< 0.0105

< 0.7548

< 0.0105

T-cells CD3⁺CD4⁺

< 0.0006

< 0.6388

< 2.9E^-05

< 3.4E^-06

< 1.4E^-05

< 2.8E^-06

< 0.2031

T-cells CD3⁺CD8⁺

< 0.0006

< 0.6356

< 3.8E^-06

< 8.1E^-06

< 4.7E^-06

< 1.6E^-05

< 0.4174

CD4⁺/CD8⁺ ratio

< 0.0007

< 0.6470

< 7.9E^-06

< 7.9E^-06

< 1.5E^-05

< 7.9E^-06

< 0.6470

NK CD56^dimCD16⁺

< 0.0144

< 0.0009

< 0.6082

< 0.6082

< 0.0014

< 0.0014

1

NK CD56^highCD16⁺

< 0.0197

< 0.0474

< 0.0077

< 0.0008

< 0.2592

< 0.0449

< 0.2396

NK CD56^dimCD16^-

< 0.0144

< 0.0009

< 0.6082

< 0.6082

< 0.0014

< 0.0014

1

NK CD56^-CD16⁺

< 0.0002

< 5.8E^-08

< 6.9E^-08

< 0.0013

< 0.5875

< 1.9E^-05

< 4.5E^-05

PDR

Total lymphocytes

< 0.2724

< 0.2683

< 0.4990

< 0.0141

0.5864

0.1263

0.0563

B-cells CD19⁺

< 6.4E^-06

< 5.3E-12

< 2.3E^-13

< 2.4E^-07

0.1028

0.0002

2.1E^-06

Total T-cells CD3⁺

< 0.0828

< 0.0003

< 0.0152

< 0.0208

0.1504

0.1080

0.7767

T-cells CD3⁺CD4⁺

< 0.0077

< 0.7607

< 0.0012

< 2.9E^-05

0.0006

2.3E^-05

0.1612

T-cells CD3⁺CD8⁺

< 0.0040

< 0.5344

< 8.6E^-05

< 6.4E^-06

0.0004

2.05E^-05

0.2616

CD4⁺/CD8⁺ ratio

< 0.0006

1

< 2.5E^-05

< 1.3E^-07

2.5E^-05

1.3E^-07

0.0629

NK CD56^dimCD16⁺

< 0.0005

< 3.2E-09

< 2.1E^-06

< 6.3E^-06

0.0190

0.0067

0.6143

NK CD56^highCD16⁺

< 0.0404

< 0.0300

< 4.8E^-05

< 0.0300

0.0120

1

0.0120

NK CD56^dimCD16^-

< 0.0019

< 8.0–07

< 2.5E^-07

< 0.0001

0.5242

0.0745

0.0220

NK CD56^-CD16⁺

< 0.0024

< 2.5E-05

< 1.6E^-07

< 9.0E^-06

0.0673

0.6336

0.1419