Fig. 3

DNFB + OVA induced epidermal barrier dysfunction and higher FLG mRNA expression. A TEWL values in each group. B The comparison of the expression levels of FLG gene between each group. C Representative sections of anti-filaggrin immunohistochemistry staining in each group. Typical positively stained cells are marked with arrows. D (d1) The comparison of positively stained area between acute lesions and chronic lesions. (d2,d3) The comparison of FLG mRNA expression levels and TEWL values between acute lesions and chronic lesions. (Data shows mean ± SD. Scale bar = 50 μm. significance levels of data were denoted as *P < 0.05, **P < 0.01, and ***P < 0.001, ****P<0.0001)