Fig. 2

DNFB + OVA induced typical AD-like phenotypic and histologic changes in BALB/C mice. A Representative images of H&E and Toluidine blue stained sections from each group; scale bar = 100 μm. B, C Comparison of the epidermal and full thickness of skin in mice subjected to different treatments. D The average numbers of mast cells per field. Data are representative of five randomly selected fields from each section. E Comparison of histological changes between acute phase and chronic phase in the DNFB + OVA group. (Date shows mean ± SD, significance levels of data were denoted as *P < 0.05, **P < 0.01, and ***P < 0.001, ****P<0.0001)