Fig. 8
From: Gentamicin promoted the production of CD4+CD25+ Tregs via the STAT5 signaling pathway in mice sepsis
STAT5 inhibitor abrogated GNT-mediated impacts on the percentage, apoptosis, and phenotypic and functional changes of Tregs in neonatal sepsis. The protein levels of TNF-α (a), IL-1β (b), IL-2 (c), and IL-10 (d) in LPS-induced mice treated with GNT and pimozide or STAT5-IN-1. Data are expressed as mean ± SD, n = 10. Percentage (e) and apoptosis (f, g) of CD4 + Tregs in LPS-induced mice treated with GNT and pimozide or STAT5-IN-1. Data are expressed as mean ± SD, n = 10. h The mRNA expression levels of FOXP3 and CTLA-4. Data are expressed as mean ± SD, n = 10. i The protein expression levels of FOXP3 and CTLA-4. Data are expressed as mean ± SD, n = 3. *P < 0.05 versus control group; #P < 0.05 versus LPS group; $P < 0.05 versus LPS + GNT group