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Fig. 5 | BMC Immunology

Fig. 5

From: Interleukin-22 protects from endotoxemia by inducing suppressive F4/80+Ly6GhiLy6Chi cells population

Fig. 5

Pivotal function of F-652 in LPS-induced endotoxemia. In the LPS induced endotoxemia model, LPS are rapidly recognized by pathogen recognition receptors (PRRs), such as Toll-like receptor (TLR4), which can initiate highly specific pro-inflammatory signaling pathways, and release a lot of pro-inflammatory cytokines. F-652 can induced the expression of S100A9 in liver, and S100A9 induced M2 macrophages polarization to suppression of excessive inflammation

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BMC Immunology

ISSN: 1471-2172

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