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Fig. 4 | BMC Immunology

Fig. 4

From: The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes

Fig. 4

Transcriptomic definition of TFRs and TFH cells. A PCA plot of gene expression data of TFR and TFH cells. B Volcano plot depicting genes differentially expressed genes between TFRs and TFH cells, highlighting top 40 genes. Each colored dot denotes an individual gene passing our p value and fold difference thresholds, grey dots represent the genes below the selected threshold (0.05). Heatmap of TFR and TFH cells representing differentially expressed C surface molecules and D Transcription factors. E RNA-Seq WGCNA modules. The colors represent each module. WGCNA functional enrichment with hub genes for TFRs F and G TFH cells

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BMC Immunology

ISSN: 1471-2172

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