Figure 2

Proinflammatory cytokine production by freshly isolated CD11+ APCs upon stimulation. Freshly isolated CD11c+ APCs from the BAL, lung parenchyma, and the spleen were cultured for 48 h with LPS or mycobacterial antigens (Mtb-CF). Culture supernatants were measured for TNF-α (A) and IL-12 (B) by ELISA. Results are representative of three independent experiments and are presented as mean ± SD. *p < 0.05 compared to the corresponding lung data. #p < 0.05 compared to the corresponding spleen data.