Figure 4

A RAR-α agonist specifically induces Th2-associated cytokine production by anti-CD3,-activated PBMC. IL-4, IL-5, and IL-13 proteins were quantitated by ELISA in supernatants of 48 h, anti-CD3,-activated PBMC treated with EtOH, ATRA (10-7 M), the RAR-α agonist, AM580 (10-7 M), or an RAR- α antagonist, RO 41-5254 (10-7 M). The values shown represent the average obtained from 4 donors ± SEM. Means that express different superscripts are significantly different by at least p < 0.02.