Figure 1

The effects of various clinically-utilized retinoid compounds on Th2-associated cytokine production by anti-CD3e-activated PBMCs. Supernatants of anti-CD3e-activated PBMCs treated with EtOH or 10-9 to 10-6 M ATRA (○), 9-cis-RA (□), 13-cis-RA (●), or 4-HPR (■) for 48 h were examined for IL-4 or IL-5. The values shown represent the average fold change obtained from 4 donors.