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Table 1 Genes responsive to LPS that are known NF-κB targets or that have putative sites κB sites

From: Transcriptional profiling of the LPS induced NF-κB response in macrophages

Accession no

Symbol

Gene Name

Reference

Chemokines and receptors

[genebank:NM_002983]

CCL3

Chemokine, CC motif, Ligand 3 π

[25]

[genebank:NM_002984]

CCL4

Chemokine, CC motif, ligand 4 π

[25]

[genebank:NM_005408]

CCL13

Chemokine, CC motif, ligand 13

[68]

[genebank:NM_032964]

CCL15

Chemokine, CC motif, ligand 15

[69]

[genebank:NM_006274]

CCL19

Chemokine, CC motif, ligand 19

-1748*

[genebank:NM_002990]

CCL22

Chemokine, CC motif, ligand 22 π

[70]

[genebank:NM_001511]

CXCL1

Chemokine CC motif, Ligand 1 π

[25]

[genebank:NM_002089]

CXCL2

Chemokine, CXC motif, ligand 2 π

[25]

[genebank:NM_000584]

CXCL8

Chemokine, CXC motif, ligand 8 π

[25]

[genebank:NM_001565]

CXCL10

Chemokine, CXC motif, ligand 10

[25]

[genebank:NM_005408]

CXCL13

Chemokine, CXC motif, ligand 13

-1593*

[genebank:U28934]

CCR2

Chemokine, CC motif, receptor 2

-1543*

[genebank:NM_003467]

CXCR4

Chemokine, CXC motif, receptor 4 π

[71]

Cytokines and Receptors

[genebank:NM_000594]

TNF-α

Tumour Necrosis Factor α π

[25]

[genebank:NM_000576]

IL1-β

Interleukin 1 B π

[25]

[genebank:NM_000577]

IL1-RN

Interleukin 1 receptor antagonist π

[25]

[genebank:NM_005746]

PBEF

Pre B cell colony stimulating factor 1 π

-533*, -479*

[genebank:NM_001250]

TNFRSF5

TNF receptor superfamily, member 5

[72]

[genebank:NM_001561]

TNFRSF9

TNF receptor superfamily member 9

[73]

[genebank:NM_005534]

IFNGR2

Interferon, gamma receptor 2

-317, -220*, -144, -134*

Stress

[genebank:NM_000636]

SOD2

Superoxide dismutase 2 πp

[25]

[genebank:NM_000963]

COX2

Cycloxygenase 2 π

[25]

[genebank:NM_006427]

TXNIP

Thioredoxin interacting protein π

-618

Apoptosis

[genebank:NM_015675]

GADD45 β

Growth arrest and DNA damage inducible gene GADD45, B π

[74]

[genebank:NM_005879]

TRIP

Traf interacting protein

-1736

[genebank:NM_006290]

TNFAIP3

Tumour Necrosis factor α induced protein 3 π

[25]

[genebank:NM_001165]

cIAP2

Cellular inhibitor of apoptosis 2 π

[75]

Transcription

[genebank:NM_020529]

IκB-α

Inhibitor of κlight chain gene enhancer in B cells; α π

[25]

[genebank:NM_003998]

NFκB1

Nuclear factor of κB, subunit 1 π

[25]

[genebank:NM_002908]

C-REL

V-rel avain reticuloendotheliosis viral oncogene homolog; rel π

[25]

[genebank:NM_005375]

C-MYB

V-MYB avian myeloblastosis viral oncogene homolog π

[25]

[genebank:NM_004364]

CEBPα

CAAT/enhancer binding protein α

[25]

[genebank:U96131]

TRIP13

Thyroid hormone interactor 13

-1611, -1601*, -1600* -1464*

[genebank:NM_002129]

HMGB2

High mobility group box 2

-1531, -1520, -1087

Cell Cycle/Differentiation

[genebank:NM_006763]

BTG2

B-cell translocation gene 2 π

[76]

[genebank:NM_002166]

ID2

Inhibitor of DNA binding 2 π

-571*, -174

[genebank:X54941]

CKS1B

CDC28 protein kinase 1B

-1416, -1406* -717, -647, -637*, -646 -636*

[genebank:NM_004701]

CCNB2

Cyclin B2

-1387

Growth

[genebank:NM_000598]

IGFBP3

Insulin-like growth-factor binding protein 3 π

-1729

Miscellaneous

[genebank:NM_000674]

ADORA1

Adenosine A1 receptor

[25]

[genebank:NM_000201]

ICAM1

Intracellular adhesion molecule 1 π

[25]

[genebank:NM_002421]

MMP1

Matrix metalloproteinase 1

[25]

[genebank:X13895]

SAA3P

Serum amyloid A3 pseudogene

-1790*

[genebank:NM_002291]

LAMβ1

Laminin, β 1

-263, -253

[genebank:NM_004119]

FLT3

FMS related tyrosine kinase 3

-295, -285*

[genebank:NM_001365]

DLG4

Discs, large homolog 4

-1425, -1415*, -544*

[genebank:M22001]

F13A1

Coagulation factor X111, A1 polypeptide

-404, -72*

  1. LPS responsive genes that have been shown to be NF-κB targets (Reference is indicated) or contain putative κB sites. The position of the site in relation to the initiator ATG is indicated and * indicates the site is found on the reverse strand. π indicates genes validated using real time PCR.
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BMC Immunology

ISSN: 1471-2172

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