Figure 3

Vibratome section from the lumbar spinal cord of a rat in which EAE was induced by an intraperitoneal injection of 5 × 106 TMBPGFP cells. A: Five days post application (peak of paraparesis) the green fluorescent autoaggressive T-lymphocytes (empty arrows) have infiltrated both white and grey matter. B: The assumption that the bulk of TMBPGFP cells would stay in contact with the red (FR-labeled) SPM (arrows) was wrong: most lymphocytes succeeded to find a way towards the CNS parenchyma.