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Figure 3 | BMC Immunology

Figure 3

From: Phenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsets

Figure 3

Expression of surface antigens, cytokines, and costimulatory molecules by PD-1-expressing T cells. (A) Flow cytometric analysis of the surface antigen expression by freshly isolated tonsil T cells is shown as graphs and dot plots. (B) Intracellular cytokine expression by CXCR5+ PD-1+ CD4+ T cells. The T cells were surface-stained and, then, activated with PMA and ionomycin in the presence of monensin for 4 h. The CXCR5+ PD-1+ CD4+ T cells are gated excluding the largely PD-1-negative naive T cells. Representative data out of 3 independent experiments are shown. (C) Surface expression of ICOS and OX40 and intracellular expression of CD40L by freshly prepared PD-1-expressing T cells. Combined data of 3 independent experiments are shown in the graphs. "*" and "**"indicate significant differences from naïve T cells and PD-1++ cells respectively.

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BMC Immunology

ISSN: 1471-2172

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