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Figure 3 | BMC Immunology

Figure 3

From: In vitro and in vivo protective efficacies of antibodies that neutralize the RNA N-glycosidase activity of Shiga toxin 2

Figure 3

Dose-dependent Neutralization of the RNA-NGA of Stx2 by the best HeLa cell cytotoxicity- and RNA-NGA-neutralizing HuMAbs 2F10, 3E9 and 5C12. The differences in neutralizing efficiency were certainly apparent at the lower doses of 46.8 ng and 23.4 ng. At 46.8 ng dose, the quantitative expression of luciferase band in presence of 2F10, 3E9 and 5C12 relative to when Stx2 was absent was 0.68, 0.65 and 0.81, respectively. At 23.4 ng dose, the relative expression of luciferase band in presence of 2F10, 3E9 and 5C12 was 0.54, 0.51 and 0.70. The experiment was repeated once with similar results.

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BMC Immunology

ISSN: 1471-2172

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