Figure 5

Anti-HIV activity of the apolipoprotein B derived peptide apoBdpL/R-W. (A) ApoBdpL/R-W has potent activity against a number of HIV strains, including both CXCR4 and CCR5 co-receptor using strains, similar to that we previously reported for apoEdpL-W. Experiments were performed by treating TZMbl cells with peptide prior to introducing the CXCR4 using HIV strain HIV NL4.3, the CCR5 using HIV strain BaL, and the dual co-receptor using HIV strain 89.6. Values show level of HIV infection (in RLU) relative to untreated control; bars indicate standard errors. No effect was seen on growth of TZMbl cells over the concentration range tested against HIV. ApoBdpL-W does not inhibit VSV-g infection (B) or cause haemolysis (C) suggesting its activity is relatively selective.